Getting Started

Explore our guides and examples to design your genetic systems.

Welcome to our Docs

Work in progress. 😁

De Novo DNA's Mission

Our mission is to make it easy for YOU to engineer organisms with less trial-and-error, leveraging state-of-the-art models & algorithms for automated genetic system design.

Biology is the Ultimate Matter-Energy-Information Converter. As new societal challenges arise, Synthetic Biologists are engineering organisms to create sustainable solutions. Living therapeutics that detect and counteract disease. Smart cellular factories that optimally produce valuable products from renewable feedstocks. Engineered ecosystems that reduce fertilizer consumption and reverse climate change.

Engineering Biology Remains Challenging. Unlike other engineering disciplines, Synthetic Biology's design-build-test cycle requires too many rounds of experimentation, wasting time and resources, and deepening the valley of entrepreneurial death. Organisms are shockingly complex; the simplest microbe has more moving parts than a SpaceX rocket. And yet, once we know which organism to build, they are shockingly cheap to mass-produce.

Engineering Biology is a Design Problem. An organism's genetic system tells it what to do, but a genetic system with only 10,000 DNA letters has more than$10^{5000}$design choices ($10^{75}\textrm{-fold}$more atoms than in the entire Universe). Selecting the best-possible DNA sequence for a large genetic system is an impossible task, even for an expert with decades of experience. There are too many components, coupled interactions, and competing effects that change from one organism to the next.

De Novo DNA Delivers Predictive Design. We empower Synthetic Biologists to engineer new organisms with much less trial-and-error. Our software platform enables Synthetic Biologists to rationally engineer new organisms with desired functionalities, utilizing our predictive models and design algorithms with an intuitive code-free interface. Under the hood, our models utilize a range of techniques (thermodynamics, kinetics, machine learning) that are combined together using advanced multi-objective optimization.

Creativity with Less Uncertainty. Designing an organism is like designing a product. You start with the challenge and creatively work backwards. But getting that organism to work correctly is frustrating and full of uncertainty, sapping your creativity. De Novo DNA eliminates uncertainty by designing genetic system sequences that achieve your target expression levels, while removing problematic & confounding sequences that disrupt your experiments. De Novo DNA also optimizes your genetic system performance by designing a small number of variants that search a large function space. And if the best target expression levels aren't known yet, De Novo DNA will help you find them in a single design-build-test cycle.

Save Time. Save the World.

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